They are seeking to recruit post-doctoral felows and PhD students in the areas of cell biology and molecular neuroscience. The Haucke laboratory aims to understand how celuter membranes and membrane-enclosed compartments dynamically exchange materials between them and its implications for cell signaling in health and disease.
Postdoctoral and PhD Student Positions
There main focus is on the endocytic and endolysosomal system that they study in genome-engineered cell lines and in nerve cells or tissue [recent publications: von Keist et al (2011) Cell 140 471-484, Posor et al (2013) Nature 409: 233-237: Ketet et al. (2016) Nature 529 408-412: Marat et al. (2017) Science 356: 968-972: Soykan et al (2017) Neuron 93 854-860, Vukoja et al (2018) Neuron 99 1216-1232: Lopez-Hemandez, T. et al (2020) Nat Cell Biol 22:815-27, Rizalar, Roosen Haucke (2021) Neuron 109,27-41, doi:10.1016/j.neuron2020.09.0038. Kuijpers et al (2021) Neuron 109,299-313, do 10.1016/j.neuron2020. 10.005, Lopez-Hemandez, T. et al (2022) L1171198, Lo et al (2022) Nat Struct Mol Biol. 29, 218-2283.
The current projects, which are supported by several recently acquired third-party grants including the European Research Council (ERC) and the German National Funding Agency (DFG), focus on the following
1) Based on the recent discovery of a novel pathway that regulates the biogenesis of autophagosomes and lysosomes in response to cellular stress (Lopez-Hemandez. T. et al (2020) Nat Cell Biol 22.815-27), They seek to explore in a cell biology project funded by the DFG (Research Unit Lysosomes, FOR 2625) how osmotic stress and other stimuli regulate exo-endocytosis to control the biogenesis and function of lysosomes and autophagosomes and how this may relate to human disease To this aim we use a combination of CRISPR genome engineering, proteomics, live imaging as well as correlative light and electron microscopy approaches
2) In a collaborative neuroscience project, we seek to unravel the role of mTORCT signaling and protein translation in memory consolidation in the mammalian brain. We will combine genetic and pharmacological manipulations with biochemical and cell biological approaches to identify the major targets of mTORCT signaling in the brain and examine celular and molecular events that are induced by an enriched environment known to facilitate learning.
They will then use this information to study the impact of altered mTORC1 activity of protein translation on memory consolidation in the neocortex
3) In a molecular neuroscience project funded by the ERC genome engineering in stemm cell-derived neurons and genetically altered mice will be combined with proteomic, high resolution imaging [see eg Lehmann et al (2019) Science Adv. 5: eaxx5775) and systems biology approaches developed in the Haucke lab to identify the origin and composition of synaptic vesicle and active zone precursors, dissect the mechanisms of their axonal transport see sg. Vukoja et al (2018) Neuron 09, 1216-1232.67; Rizalar, Roosen, Haucks (2021) Neuron doi:10.1016) neuron 2020.09.0381 and integration into developing synapses.
The overall goal is to unravel the pathway that controls axonal transport and presynaptic assembly of newly made presynaptic proteins to set synaptic weight.
Candidates will have the opportunity to refine their management skits by the design and supervision of student research projects (BSc and MSc), and will benefit from a broad variety of advanced training opportunities.
Qualifications : Postdoctoral and PhD Student Positions
They seek highly motivated, ambitious, and talented young scientists to join an enthusiastic and collaborative team in an outstanding scientific environment to perform research. Successful postdoc applicants will hold a Ph.D. in a relevant area (e.g. cell biology, molecular biology. biochemistry, neuroscience, physiology) and have a strong track record of accomplishment.
Postdoc candidates with proven interests and/ or experience in proteomics, microscopical imaging techniques (e.g. high-resolution light or electron microscopy) and/ or the use and application of stem cell-based neurons or brain organoids are especially encouraged to apply.
PhD student candidates should have a master’s degree in molecular biology, biochemistry. biophysics, or related fields.
All applicants are expected to benefit from excellent written and oral communication skills and display a high personal motivation to excel in science. The working language is English; knowledge of the German language is not required.
The Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP) is a non-university research institute that conducts basic research in molecular pharmacology and provides a vibrant and collaborative environment with state-of-the-art facilities for research and employees from all over the world.
The Haucke lab is embedded into the NeuroCure Cluster of Excellence (see: http://www.neurocure.de), a collaborative framework program that bines leading researchers in neuroscience from various Berlin based institutions. Since combines 2013, the FMP has been awarded with the certificate of the audit “Beruf und Familie” as family friendly employer.
They offer equal opportunities regardless of gender and welcome applications of f disabled candidates, who will be preferred in case of equal qualification. We welcome applications from all backgrounds. take and share responsibility: The Haucke lab is the first certified green lab in Germany. We take
Are you interested?
Then please submit your complete application documents, containing a one-page letter with a personal statement describing your scientific accomplishments and your interests in our laboratory, your CV and bibliography as well as, contact information for 3 references, in electronic form as one single pdf-file via e-mail to [email protected].
Applications will be considered upon submission. The positions are available from 1 July 2022 (or later) and are based on contracts for the civil service (TVöD). They will be time limited for an initial period of two years with the possibility of extension up to five years.
For further information about the Institute and the Haucke department see www.leibnizfmp.de/haucke.